What is Amyotrophic lateral sclerosis ?

ALS stands for Amyotrophic lateral sclerosis. one of the neurological diseases that attack certain nerve cells (neurons) in the brain that causes bone marrow to die slowly. if you know Stephen Hawking, he is one of the patient or sufferer of ALS and maybe one of the worst.
There are two types of ALS (Amyotrophic lateral sclerosis) disease, namely:
  • Upper motor neurons: Nerve cells in the brain.
  • Lower motor neurons: Nerve cells in the spinal cord.
These motor neurons control all the reflex or spontaneous movements in the muscles of your arms, legs and face. Motor neurons also function to tell your muscles to contract so that you can walk, run, lift weights around, chew and swallow food, and even breathe.

Signs & symptoms of ALS (Amyotrophic lateral sclerosis)
The initial symptoms of ALS often begin with mild muscle problems, then spread to other parts of the body. As the disease progresses, symptoms will get worse, nerve cells will be damaged, and muscles will continue to weaken so that it affects the patient's ability to talk, walk, and move other limbs and at worst the sufferer will experience complete paralysis. Although this disease attacks the nervous system, but ALS doesn't affect the sense of sight, smell, taste and hearing. so even though the sufferer is eventually paralyzed he can still feel, hear and see, it's just that he can't move.

Medicines & Medications
Until now there is no drug or treatment that can cure this disease. Current treatments and treatments are only aimed at controlling symptoms and supporting patients for as long as possible. and one of the drugs given for ALS is riluzole, this drug is only slowing the progress of ALS but its effects are limited. and there are several other drugs that can be given but are only for controlling spasms, difficulty swallowing, cramps and pain in the muscles. besides ALS patient care can also do physical therapy. the purpose of physical therapy is the same as treatment with drugs that is, only to slow the process of nerve cell damage.
Causes of Amyotrophic Lateral Sclerosis (ALS)
There is no definite evidence about the causes of ALS. However, about 5-10% of the existing cases of ALS are known to be Hereditary. In addition to heredity, several studies have shown that ALS is thought to be related to a number of conditions below:
  • Glutamate Pros: Glutamate is a chemical that acts as a sender of messages to and from the brain and nerves. However, if it builds up around nerve cells, glutamate can cause damage to the nervous system.
  • Immune system disorders: In ALS sufferers, the immune system is sometimes attacked by healthy nerve cells, causing damage to these cells.
  • Mitochondrial disorders: Mitochondria are where energy is formed in cells. Disruption in the formation of this energy can damage nerve cells and accelerate the spread of ALS disease.
  • Oxidative stress: Excessive levels of free radicals will cause oxidative stress and cause damage to various body cells, especially nerve cells.
Those are the explanation of ALS disease ((Amyotrophic lateral sclerosis), if there are questions about this problem please leave a comment below. see you in my next article, thank you.

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